| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Caleb Williams |
1. Caleb Williams, QB | CHI | L 30-27 vs. MIN | 32 | 47 | 340 | 2 | 0 | 3 | 0 | 103.2 |
| 2. Sam Darnold, QB | MIN | W 30-27 at CHI | 22 | 34 | 330 | 2 | 0 | 3 | 0 | 116.1 | |
| 3. Tua Tagovailoa, QB | MIA | W 34-15 vs. NE | 29 | 40 | 317 | 4 | 0 | 2 | 0 | 128.9 | |
| 4. Baker Mayfield, QB | TB | W 30-7 at NYG | 24 | 30 | 294 | 0 | 0 | 0 | 1 | 107.5 | |
| 5. Kyler Murray, QB | ARI | L 16-6 at SEA | 24 | 37 | 285 | 0 | 1 | 5 | 0 | 77.0 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Saquon Barkley |
1. Saquon Barkley, RB | PHI | W 37-20 at LAR | 26 | 255 | 9.8 | 2 | 72 | 0 | |
| 2. Tony Pollard, RB | TEN | W 32-27 at HOU | 24 | 119 | 5.0 | 1 | 27 | 0 | ||
| 3. Aaron Jones, RB | MIN | W 30-27 at CHI | 22 | 106 | 4.8 | 1 | 41 | 1 | ||
| 4. Josh Jacobs, RB | GB | W 38-10 vs. SF | 26 | 106 | 4.1 | 3 | 18 | 0 | ||
| 5. Jahmyr Gibbs, RB | DET | W 24-6 at IND | 21 | 90 | 4.3 | 2 | 17 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Jordan Addison |
1. Jordan Addison, WR | MIN | W 30-27 at CHI | 8 | 162 | 20.3 | 1 | 69 | 0 | |
| 2. Jaylen Waddle, WR | MIA | W 34-15 vs. NE | 8 | 144 | 18.0 | 1 | 29 | 0 | ||
| 3. Trey McBride, TE | ARI | L 16-6 at SEA | 12 | 133 | 11.1 | 0 | 20 | 0 | ||
| 4. Jakobi Meyers, WR | LV | L 29-19 vs. DEN | 10 | 121 | 12.1 | 0 | 25 | 0 | ||
| 5. Puka Nacua, WR | LAR | L 37-20 vs. PHI | 9 | 117 | 13.0 | 0 | 29 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Nick Cross |
1. Nick Cross, S | IND | L 24-6 vs. DET | 6 | 8 | 14 | 0.0 | 0 | 0 | 0 |
| 2. Kevin Byard III, S | CHI | L 30-27 vs. MIN | 11 | 2 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Zaire Franklin, LB | IND | L 24-6 vs. DET | 8 | 5 | 13 | 1.0 | 0 | 0 | 0 | |
| 4. Josh Butler, CB | DAL | W 34-26 at WSH | 10 | 2 | 12 | 1.0 | 0 | 0 | 0 | |
| 5. Christian Rozeboom, LB | LAR | L 37-20 vs. PHI | 7 | 5 | 12 | 0.0 | 0 | 0 | 0 | |